PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation.

BACKGROUND & AIMS KPV is a tripeptide (Lys-Pro-Val), which possesses anti-inflammatory properties; however, its mechanisms of action still remain unknown. PepT1 is a di/tripeptide transporter normally expressed in the small intestine and induced in colon during inflammatory bowel disease (IBD). The aim of this study was to 1) investigate whether the KPV… CONTINUE READING