Pep2Path: Automated Mass Spectrometry-Guided Genome Mining of Peptidic Natural Products

@inproceedings{Medema2014Pep2PathAM,
  title={Pep2Path: Automated Mass Spectrometry-Guided Genome Mining of Peptidic Natural Products},
  author={Marnix H. Medema and Yared Paalvast and Don D. Nguyen and Alexey Melnik and Pieter C. Dorrestein and Eriko Takano and Rainer Breitling},
  booktitle={PLoS Computational Biology},
  year={2014}
}
Nonribosomally and ribosomally synthesized bioactive peptides constitute a source of molecules of great biomedical importance, including antibiotics such as penicillin, immunosuppressants such as cyclosporine, and cytostatics such as bleomycin. Recently, an innovative mass-spectrometry-based strategy, peptidogenomics, has been pioneered to effectively mine microbial strains for novel peptidic metabolites. Even though mass-spectrometric peptide detection can be performed quite fast, true high… CONTINUE READING
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