Pep 7 p Provides a Novel Protein that Functions in Vesicle-mediated Transport between the Yeast Golgi and Endosome Gene

@inproceedings{WebbPep7P,
  title={Pep 7 p Provides a Novel Protein that Functions in Vesicle-mediated Transport between the Yeast Golgi and Endosome Gene},
  author={Cathy Webb and Jianqing Zhang and Steven J. Garlow and Andreas Wesp and Howard Riezman and Elizabeth W. Jones}
}
Saccharomyces cerevisiae pep7 mutants are defective in transport of soluble vacuolar hydrolases to the lysosome-like vacuole. PEP7 is a nonessential gene that encodes a hydrophilic protein of 515 amino acids. A cysteine-rich tripartite motif in the N-terminal half of the polypeptide shows striking similarity to sequences found in many other eukaryotic proteins. Several of these proteins are thought to function in the vacuolar/ lysosomal pathway. Mutations that change highly conserved cysteine… CONTINUE READING

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