Peony Glycosides Protect Against Corticosterone-Induced Neurotoxicity in PC12 Cells

Abstract

Preclinical and clinical investigations have shown the involvement of dysregulation of hypothalamic–pituitary–adrenal (HPA) axis in the pathogenesis of depression. Hypercortisolemia and the associated hippocampal atrophy were observed in patients with depression, which could be ameliorated by the treatment with antidepressants. Therefore, neuroprotection… (More)
DOI: 10.1007/s10571-009-9357-7

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