Pentylenetetrazol kindling in mice.

  title={Pentylenetetrazol kindling in mice.},
  author={Ralph Karler and V F Murphy and Larry D. Calder and Stuart A. Turkanis},
  volume={28 8},
Kindling with pentylenetetrazol to produce minimal and maximal convulsions was investigated in CF-1 mice. Like electrical kindling, the kindling effect was directly proportional to the dose or the intensity of the kindling stimulus. Similarly, the kindling effect was persistent, as was emphasized by the ability to kindle with an interdose interval of 3 days and by the convulsions produced by a challenge with pentylenetetrazol 30 days after withdrawal from the kindling treatment. The changes in… CONTINUE READING
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