Pentraxins in Innate Immunity: From C-Reactive Protein to the Long Pentraxin PTX3

@article{Mantovani2007PentraxinsII,
  title={Pentraxins in Innate Immunity: From C-Reactive Protein to the Long Pentraxin PTX3},
  author={Alberto Mantovani and Cecilia Garlanda and Andrea Doni and Barbara Bottazzi},
  journal={Journal of Clinical Immunology},
  year={2007},
  volume={28},
  pages={1-13}
}
Pentraxins are a family of multimeric pattern-recognition proteins highly conserved in evolution. Based on the primary structure of the subunit, the pentraxins are divided into two groups: short pentraxins and long pentraxins. C-reactive protein and serum amyloid P-component are classic short pentraxins produced in the liver, whereas the prototype of the long pentraxin family is PTX3. Innate immunity cells and vascular cells produce PTX3 in response to proinflammatory signals and Toll-like… 
Pentraxins: Multifunctional proteins at the interface of innate immunity and inflammation
Pentraxins are a family of multimeric pattern recognition proteins highly conserved in evolution. On the basis of the primary structure of the protomer, pentraxins are divided into two groups: short
The long pentraxin PTX3 at the crossroads between innate immunity and tissue remodelling.
TLDR
A number of predominantly non-coding polymorphisms have been identified in the PTX3 gene which, when associated in particular haplotypes, have been shown to be relevant in clinical conditions including infection and fertility.
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TLDR
A proteomic study of PTX3 ligands in septic patients revealed thatPTX3 forms a complex with certain NET component proteins, which suggests a role for PTx3 in which it facilitates the efficiency of anti-microbial protein pathogen clearance by interacting with both pathogens and anti- microbial proteins.
An integrated view of humoral innate immunity: pentraxins as a paradigm.
TLDR
The innate immune system consists of a cellular and a humoral arm which also includes complement components, collectins, and ficolins and is an integrated system consisting of different molecules and sharing functional outputs with antibodies.
Pathogen Recognition by the Long Pentraxin PTX3
TLDR
The long pentraxin PTX3 is a prototypic soluble PRM that is produced at sites of infection and inflammation by both somatic and immune cells and exerts important functions at the cross-road between innate immunity, inflammation, and female fertility.
The Proteomic Profile of Circulating Pentraxin 3 (PTX3) Complex in Sepsis Demonstrates the Interaction with Azurocidin 1 and Other Components of Neutrophil Extracellular Traps*
TLDR
The association of circulating PTX3 with components of the neutrophil extracellular traps in sepsis suggests a role forPTX3 in host defense and as a potential diagnostic target.
Biology of Human Pentraxin 3 (PTX3) in Acute and Chronic Kidney Disease
TLDR
The general characteristics of PTX3 are reviewed focusing in particular on its fundamental biological functions in the course of acute and chronic kidney diseases.
Complementary Roles of Short and Long Pentraxins in the Complement-Mediated Immune Response to Aspergillus fumigatus Infections
TLDR
This crosstalk is revisited in light of the emerging roles of SAP as a novel PRM with antifungal activity and the role of complement activation and receptor-mediated phagocytosis in the immune response to A. fumigatus.
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