Pentraxins in Innate Immunity: From C-Reactive Protein to the Long Pentraxin PTX3

  title={Pentraxins in Innate Immunity: From C-Reactive Protein to the Long Pentraxin PTX3},
  author={Alberto Mantovani and Cecilia Garlanda and Andrea Doni and Barbara Bottazzi},
  journal={Journal of Clinical Immunology},
Pentraxins are a family of multimeric pattern-recognition proteins highly conserved in evolution. Based on the primary structure of the subunit, the pentraxins are divided into two groups: short pentraxins and long pentraxins. C-reactive protein and serum amyloid P-component are classic short pentraxins produced in the liver, whereas the prototype of the long pentraxin family is PTX3. Innate immunity cells and vascular cells produce PTX3 in response to proinflammatory signals and Toll-like… 

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