Pentraxin-3 modulates lipopolysaccharide-induced inflammatory response and attenuates liver injury.

@article{Perea2017Pentraxin3ML,
  title={Pentraxin-3 modulates lipopolysaccharide-induced inflammatory response and attenuates liver injury.},
  author={Luis Perea and M Regina Coll and Luc{\'i}a Sanjurjo and Delia Blaya and Adil El Taghdouini and Daniel Rodrigo-Torres and Jos{\'e} S. Altamirano and Isabel Graupera and Beatriz Aguilar-Bravo and Marta Llopis and J{\'u}lia Vallverd{\'u} and Joan Caballer{\'i}a and Leo A van Grunsven and Maria-Rosa Sarrias and Pere Gin{\`e}s and Pau Sancho-Bru},
  journal={Hepatology},
  year={2017},
  volume={66 3},
  pages={
          953-968
        }
}
Acute-on-chronic liver injury is characterized by an important inflammatory response frequently associated with endotoxemia. In this context, acute-phase proteins such as Pentraxin-3 (PTX3) are released; however, little is known about their role in chronic liver disease. The aim of this study was to elucidate the role of PTX3 in liver injury. The role of PTX3 was evaluated in cultured human cells, liver tissue slices, and mice with acute-on-chronic liver injury. PTX3 expression was assessed in… CONTINUE READING
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