Pentraxin 3 inhibits fibroblast growth factor 2-dependent activation of smooth muscle cells in vitro and neointima formation in vivo.

@article{Camozzi2005Pentraxin3I,
  title={Pentraxin 3 inhibits fibroblast growth factor 2-dependent activation of smooth muscle cells in vitro and neointima formation in vivo.},
  author={Maura Camozzi and Serena Zacchigna and Marco Rusnati and Daniela Coltrini and Genaro A. Ramirez-Correa and Barbara Bottazzi and Alberto Mantovani and Mauro Giacca and Marco Presta},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2005},
  volume={25 9},
  pages={1837-42}
}
OBJECTIVE The fibroblast growth factor (FGF)/FGF receptor system plays an important role in smooth muscle cell (SMC) activation. Long-pentraxin 3 (PTX3) is a soluble pattern recognition receptor with non-redundant functions in inflammation and innate immunity. PTX3 is produced by different cell types of the vessel wall, including SMCs. PTX3 binds FGF2 and inhibits its angiogenic activity on endothelial cells. We investigated the capacity of PTX3 to affect FGF2-dependent SMC activation in vitro… CONTINUE READING

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