Pentraxin 3(PTX 3): An Endogenous Modulator of the Inflammatory Response

  title={Pentraxin 3(PTX 3): An Endogenous Modulator of the Inflammatory Response},
  author={Pavel Kune{\vs} and Zdeňka Holubcov{\'a} and Martina Kol{\'a}ckov{\'a} and Jan Krejsek},
  booktitle={Mediators of inflammation},
Inflammatory or anti-inflammatory? That is the question as far as the acute-phase response and its mediators, the pentraxins, are concerned. Only some ten years ago, the classical or short pentraxin C-reactive protein and the newly discovered long pentraxin PTX3 were considered to exert most of the detrimental effects of acute inflammation, whether microbial or sterile in origin. However, accumulating evidence suggests an at least dichotomous, context-dependent outcome attributable to the… CONTINUE READING

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