Pentoxifylline treatment of sepsis of premature infants: Preliminary clinical observations

  title={Pentoxifylline treatment of sepsis of premature infants: Preliminary clinical observations},
  author={Ryszard Lauterbach and Dorota Pawlik and Barbara Tomaszczyk and Beata Cholewa},
  journal={European Journal of Pediatrics},
Pentoxifylline (Trental, 5 mg/kg/h for 6 h) was administered to 17 premature infants with sepsis, on 3 successive days. A statistically significant decrease in mortality rate (P < 0.04) was observed in comparison to a retrospectively analysed group of 13 septic infants, who were treated in a comparative way but without the use of a pentoxifylline infusion. The suggestion that pentoxifylline may be an effective drug in the treatment of Gram-negative sepsis in premature infants should be tested… CONTINUE READING

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