• Corpus ID: 30972289

Pentoxifylline-rescue for the oncological patient . Anticancer and protective properties of an alkaloid derivative .

  title={Pentoxifylline-rescue for the oncological patient . Anticancer and protective properties of an alkaloid derivative .},
  author={Anna Bogucka-Kocka and Anna Och and Marek Och and Janusz Kocki},
Context: Pentoxifylline is a methylxanthine derivative. Because of influence on blood flow it is a drug used in circulatory diseases. Currently pentoxifylline is under examination as regards its anticancer properties. Objective: The authors gathered and systemized the knowledge about anticancer activity of pentoxifylline and knowledge about the progress of studies and clinical triails in this subject. Methods: More than 80 Englishlanguage abstracts were analyzed and complete texts of selected… 



Unravelling the antimetastatic potential of pentoxifylline, a methylxanthine derivative in human MDA-MB-231 breast cancer cells

PTX at non-toxic doses affected cellular proliferation, adhesion, migration and invasion, and demonstrated its anti-metastatic effect on MDA-MB-231 cells, and further studies need to be carried out to understand the mechanism of action.

Suramin augments the antitumor and antimetastatic activity of pentoxifylline in B16F10 melanoma

The novel combination of PTX and suramin has synergistic antitumor and antimetastatic activity in B16F10 melanoma and may be a promising approach in treatment of patients suffering from malignant melanoma.

Antiproliferative and Antiproteolytic activity of Pentoxifylline in cultures of B16F10 Melanoma cells

The results suggest that PTX even at non-toxic pharmacological concentrations acts as an effective antiproliferative agent with significant antiproteolytic and antiadhesive effects.

Potentiation of Anticancer Drugs: Effects of Pentoxifylline on Neoplastic Cells

It is concluded that PTX induces the sensitization of multidrug-resistant cells to VCR via downregulation of P-gp, stimulation of apoptosis and reduction of MMPs released from drug-resistant L1210/VCR cells.

[Cytotoxicity of pentoxifylline and its effect on human hepatoma cell line Hep3b radiosensitivity].

Radiosensitization by PTX is possibly associated with the abrogation of G(2)/M arrest in Hep3b cells following radiation exposure, suggesting that potential clinical application of PTX may enhance the efficacy of radiotherapy against hepatocellular carcinoma.

Pentoxifylline and its major oxidative metabolites exhibit different pharmacological properties.

Results of combination therapy with amifostine, pentoxifylline, ciprofloxacin and dexamethasone in patients with myelodysplastic syndrome and acute myeloid leukemia

It was found that amifostine + PCD combination may be beneficial in reversing cytopenias in the treatment of MDS and AML and is worth further study.

In vitro Induction of Apoptosis in U937 Cells by Perillyl Alcohol with Sensitization by Pentoxifylline: Increased BCL-2 and BAX Protein Expression

PTX sensitizes tumor cells to the anti-neoplastic action of P-OH, suggesting that the effects of PTX might be attributable to changes in the mitochondrial membrane potential.

Sensitization of cervix cancer cells to Adriamycin by Pentoxifylline induces an increase in apoptosis and decrease senescence

Surprisingly, in spite of the antitumor activity displayed by PTX, the results indicate that methylxantine, per se does not induce senescence; however it inhibits Senescence induced by ADR and at the same time increases apoptosis.

Pharmacokinetic interaction between verapamil and methylxanthine derivatives in mice.

  • E. Wyska
  • Biology, Medicine
    Drug metabolism letters
  • 2010
The interaction between verapamil and pentoxifylline is, at least partially, P-glycoprotein-mediated, whereas alterations in lisofylline pharmacokinetics are caused by inhibition of drug metabolising enzymes.