Pentoxifylline reduces the inflammatory process in diabetic rats: relationship with decreases of pro-inflammatory cytokines and inducible nitric oxide synthase

@article{Garcia2015PentoxifyllineRT,
  title={Pentoxifylline reduces the inflammatory process in diabetic rats: relationship with decreases of pro-inflammatory cytokines and inducible nitric oxide synthase},
  author={F. A. O. Garcia and J{\'e}ssica Farias Rebouças and Teresa Queiroz Balbino and T. G. da Silva and Carlson H{\'e}lder Reis de Carvalho-J{\'u}nior and G. Cerqueira and G. Brito and G. Viana},
  journal={Journal of Inflammation (London, England)},
  year={2015},
  volume={12}
}
Studies suggest that inflammation is a key factor in the pathogenesis of diabetes mellitus. Pro-inflammatory cytokines, such as IL-6 and TNF-alpha, are produced by adipose tissue in large quantities, in obese and especially in diabetic individuals. Pentoxifylline (PTX) is a non-selective phosphodiesterase inhibitor with anti-inflammatory and antioxidant actions that may contribute to alleviate diabetes side effects, as neuropathy, retinopathy and nephropathy. This study aims to investigate PTX… Expand
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References

SHOWING 1-10 OF 80 REFERENCES
Chlorpropamide treatment restores the reduced carrageenan-induced paw edema and pleural exudate volume in diabetic rats
Phosphodiesterase Inhibitor Improves Renal Tubulointerstitial Hypoxia of the Diabetic Rat Kidney
Glibenclamide attenuates myocardial injury by lipopolysaccharides in streptozotocin-induced diabetic mice
Pentoxifylline Ameliorates Renal Tumor Necrosis Factor Expression, Sodium Retention, and Renal Hypertrophy in Diabetic Rats
Cytokine profiles during carrageenan-induced inflammatory hyperalgesia in rat muscle and hind paw.
Pentoxifylline inhibits endotoxin-induced NF-kappa B activation and associated production of proinflammatory cytokines.
...
1
2
3
4
5
...