Pentoxifylline inhibits the synthesis and IFN-gamma-inducing activity of IL-18.

  title={Pentoxifylline inhibits the synthesis and IFN-gamma-inducing activity of IL-18.},
  author={Tatjana Samardzic and Violeta Jankovi{\'c} and Stanislava D. Sto{\vs}i{\'c}-Gruji{\vc}i{\'c} and Dusan M Popadic and Vladimir Trajkovic},
  journal={Clinical and experimental immunology},
  volume={124 2},
The effect of phosphodiesterase-inhibiting anti-inflammatory drug pentoxifylline (PTX) on LPS-induced IL-18 synthesis and IL-18-mediated IFN-gamma-induction were investigated. In a dose-dependent manner PTX inhibited production of IL-18 in LPS-treated cultures of murine spleen cells and bone marrow-derived macrophages. Similarly, PTX treatment significantly reduced blood IL-18 levels and expression of spleen IL-18 mRNA in LPS-challenged mice. The inhibitory effect of PTX was specific for IL-18… CONTINUE READING