Pentoxifylline inhibits perforin-dependent natural cytotoxicity in vitro.

  title={Pentoxifylline inhibits perforin-dependent natural cytotoxicity in vitro.},
  author={Marta Alicja Lazarczyk and Tomasz Grzela and Grażyna Korczak-Kowalska and Justyna Niderla and Monika Oldak and Jarosław J{\'o}źwiak and Piotr Skopinski},
  journal={Oncology reports},
  volume={9 2},
Pentoxifylline (PTX) is commonly used in peripheral blood vessel diseases, however it has also been found to decrease the level of proinflammatory cytokines such as IL-12, TNF-alpha and IFN-gamma. Moreover, some authors reported that PTX suppresses spontaneous cytotoxicity of peripheral blood mononuclear cells (PBMC) in vitro. It could influence the… CONTINUE READING