Pentoxifylline inhibits adhesion and activation of human T lymphocytes.

@article{GonzlezAmaro1998PentoxifyllineIA,
  title={Pentoxifylline inhibits adhesion and activation of human T lymphocytes.},
  author={Roberto Gonz{\'a}lez-Amaro and Diana Patricia Portales-P{\'e}rez and Lourdes Baranda and Juan Miguel Redondo and Sara Mart{\'i}nez-Mart{\'i}nez and Mar{\'i}a Y{\'a}{\~n}ez-M{\'o} and Rosario Garc{\'i}a-Vicu{\~n}a and Carlos Caba{\~n}as and Francisco S{\'a}nchez-Madrid},
  journal={Journal of immunology},
  year={1998},
  volume={161 1},
  pages={65-72}
}
We have herein studied the effect of pentoxifylline (PTX) on the adhesion and activation of human T lymphocytes. We found that PTX inhibited the adhesion of T cells to the beta1 and beta2 integrin ligands VCAM-1 and ICAM-1; this inhibitory activity was dose dependent, with a maximal effect from 12 to 24 h. We also found that PTX was able to interfere with the activation of beta1 integrins induced by intracellular signals; however, the conformational change of beta1 integrins induced by… CONTINUE READING