Pentoxifylline inhibits TLR- and inflammasome-mediated in vitro inflammatory cytokine production in human blood with greater efficacy and potency in newborns

@article{Speer2017PentoxifyllineIT,
  title={Pentoxifylline inhibits TLR- and inflammasome-mediated in vitro inflammatory cytokine production in human blood with greater efficacy and potency in newborns},
  author={Esther M Speer and David J. Dowling and Lukasz S. Ozog and Jianjin Xu and Jie Yang and Geetika Kennady and Ofer Levy},
  journal={Pediatric Research},
  year={2017},
  volume={81},
  pages={806-816}
}
Background:Toll-like receptor (TLR)-mediated inflammation may contribute to neonatal sepsis, for which pentoxifylline (PTX), a phosphodiesterase inhibitor that raises intracellular cAMP, is a candidate adjunctive therapy. We characterized the anti-inflammatory effects of PTX toward TLR-mediated production of inflammatory (tumor necrosis factor (TNF) and interleukin (IL)-1β) and proresolution (IL-6 and IL-10) cytokines in human newborn and adult blood.Methods:Newborn cord and adult blood were… 

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