Pentoxifylline in vivo and in vitro down-regulates the expression of the intercellular adhesion molecule-1 in monocytes.

@article{Neuner1997PentoxifyllineIV,
  title={Pentoxifylline in vivo and in vitro down-regulates the expression of the intercellular adhesion molecule-1 in monocytes.},
  author={Peter Neuner and Gabriele Klosner and Mojgan Pourmojib and Robert Knobler and Thomas Schwarz},
  journal={Immunology},
  year={1997},
  volume={90 3},
  pages={435-9}
}
Since pentoxifylline (PTX) was recently recognized as a substance with antiinflammatory capacities, we studied the in vivo and in vitro effect of PTX on the expression of the intercellular adhesion molecule-1 (ICAM-1) on human monocytes. For this purpose four healthy volunteers were treated with PTX (5 x 400 mg/day) for 2 days. Monocytes were isolated before and after PTX treatment and ICAM-1 expression was investigated. As shown by fluorescence-activated cell sorter (FACS) analysis, cultured… CONTINUE READING

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