Pentoxifylline in prevention of radiation-induced lung toxicity in patients with breast and lung cancer: a double-blind randomized trial.

@article{Ozturk2004PentoxifyllineIP,
  title={Pentoxifylline in prevention of radiation-induced lung toxicity in patients with breast and lung cancer: a double-blind randomized trial.},
  author={Berrin Ozturk and Ibrahim Egehan and Sevil G Atavci and Mehmet Teufik Kitapci},
  journal={International journal of radiation oncology, biology, physics},
  year={2004},
  volume={58 1},
  pages={213-9}
}
PURPOSE Pentoxifylline (Ptx) is thought to be helpful in preventing radiotoxicity by inhibiting platelet aggregation and tumor necrosis factor. We assessed whether prophylactic use of Ptx could prevent early and late normal lung tissue damage due to radiotherapy in a double-blind, randomized trial. METHODS AND MATERIALS A total of 40 patients with lung or breast cancer were randomized to receive Ptx (400 mg) or a placebo, 3 times daily, during the entire period of radiotherapy. We used the… CONTINUE READING
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