Pentoxifylline decreases body weight loss and muscle protein wasting characteristics of sepsis.

  title={Pentoxifylline decreases body weight loss and muscle protein wasting characteristics of sepsis.},
  author={Denis Breuill{\'e} and Marie Farge and Frank Rose and M L Arnal and Didier Attaix and Christiane Obled},
  journal={The American journal of physiology},
  volume={265 4 Pt 1},
Sepsis induces metabolic disorders that include loss of body weight, muscle wasting, and acute-phase protein synthesis in liver. Cytokines are generally recognized as active mediators of these disorders, and the implication of tumor necrosis factor (TNF) has been frequently discussed in the recent past. However, the identity of the active agent in alterations of protein metabolism is still controversial. To improve our understanding of the role of cytokines in mediating muscle wasting observed… CONTINUE READING


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