Pentoxifylline attenuates cardiac dysfunction and reduces TNF-alpha level in ischemic-reperfused heart.

@article{Zhang2005PentoxifyllineAC,
  title={Pentoxifylline attenuates cardiac dysfunction and reduces TNF-alpha level in ischemic-reperfused heart.},
  author={Ming Zhang and Yanjun Xu and Harjot K. Saini and Belma Turan and Peter Liu and Naranjan S. Dhalla},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2005},
  volume={289 2},
  pages={H832-9}
}
Although pentoxifylline (PTXF), a phosphodiesterase inhibitor, has been reported to exert beneficial effects in cardiac bypass surgery, its effect and mechanisms against ischemia-reperfusion (I/R) injury in heart are poorly understood. Because I/R is known to increase the level of tumor necrosis factor (TNF)-alpha in myocardium and PTXF has been shown to depress the production of TNF-alpha in failing heart, this study examined the hypothesis that PTXF may attenuate cardiac dysfunction and… CONTINUE READING

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