Pentoxifylline attenuates iminodipropionitrile-induced behavioral abnormalities in rats

  title={Pentoxifylline attenuates iminodipropionitrile-induced behavioral abnormalities in rats},
  author={Saeed Al Kadasah and Ahmad Al Mutairy and M. Siddiquei and Haseeb Ahmad Khan and Ibrahim Abdulwahid Arif and K. Al Moutaery and M. Tariq},
  journal={Behavioural Pharmacology},
This investigation was undertaken to study the effect of pentoxifylline (PTX) on iminodipropionitrile (IDPN)-induced behavioral abnormalities [excitation with choreiform and circling movements (ECC) syndrome] in rats. The animals were intraperitoneally injected with IDPN (100 mg/kg) daily for 7 days. PTX was administered daily 30 min before IDPN in the doses of 25, 50, and 100 mg/kg for 9 days. The animals were observed for neurobehavioral abnormalities including dyskinetic head movements… Expand
10 Citations
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