Pentoxifylline and other protein kinase C inhibitors down-regulate HIV-LTR NF-kappa B induced gene expression.

@article{Biswas1994PentoxifyllineAO,
  title={Pentoxifylline and other protein kinase C inhibitors down-regulate HIV-LTR NF-kappa B induced gene expression.},
  author={Debajit K. Biswas and Christoph Matthias Ahlers and Bruce J. Dezube and Arthur B. Pardee},
  journal={Molecular medicine},
  year={1994},
  volume={1 1},
  pages={
          31-43
        }
}
BACKGROUND This investigation deals with the molecular mechanism of anti-human immunodeficiency virus type 1 (HIV-1) action of pentoxifylline (PTX) [1-(5'-oxohexyl)-3, 7-dimethylxanthine] a drug widely used for the treatment of conditions involving defective regional microcirculation. MATERIALS AND METHODS The inhibition by PTX of protein kinase C (PKC) or cAMP-dependent protein kinase (PKA)-mediated activation by phorbol ester (PMA) and tumor necrosis factor alpha (TNF-alpha) of HIV-1-LTR… CONTINUE READING

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