Pentostatin and cyclophosphamide: an effective new regimen in previously treated patients with chronic lymphocytic leukemia.

@article{Weiss2003PentostatinAC,
  title={Pentostatin and cyclophosphamide: an effective new regimen in previously treated patients with chronic lymphocytic leukemia.},
  author={Mark A. Weiss and Peter G. Maslak and Joseph Jurcic and David A. Scheinberg and Timothy B Aliff and Nicole Lamanna and Stanley R. Frankel and Steven E Kossman and Denise Horgan},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2003},
  volume={21 7},
  pages={1278-84}
}
PURPOSE Purine analogs and alkylators are important agents in the treatment of chronic lymphocytic leukemia (CLL). Previously, combinations of fludarabine and chlorambucil were abandoned because of increased toxicity from overlapping myelosuppression and immunosuppression. Of the purine analogs active in CLL, pentostatin may be least myelosuppressive. We hypothesized that combining pentostatin with cyclophosphamide would have less myelotoxicity than combinations using other purine analogs… CONTINUE READING

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