Pentose phosphate metabolism in Leishmania mexicana.

  title={Pentose phosphate metabolism in Leishmania mexicana.},
  author={Dante Abel Maugeri and Juan Jos{\'e} Cazzulo and Richard J. Burchmore and Michael P. Barrett and Patrick O J Ogbunude},
  journal={Molecular and biochemical parasitology},
  volume={130 2},
The metabolism of pentose phosphates was studied in Leishmania mexicana promastigotes. Each of the enzymes of the classical pentose phosphate pathway (PPP) has been identified and specific activities measured. Functioning of the PPP was demonstrated in non-growing cells by measuring the evolution of 14CO2 from [1-14C]D-glucose and [6-14C]D-glucose under normal conditions and also under selective stimulation of the PPP by exposure to methylene blue. The proportion of glucose which passes through… CONTINUE READING
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