Corpus ID: 42878824

Pentosan polysulfate (Cartrophen) prevents the hydrocortisone induced loss of hyaluronic acid and proteoglycans from cartilage of rabbit joints as well as normalizes the keratan sulfate levels in their serum.

@article{Kongtawelert1989PentosanP,
  title={Pentosan polysulfate (Cartrophen) prevents the hydrocortisone induced loss of hyaluronic acid and proteoglycans from cartilage of rabbit joints as well as normalizes the keratan sulfate levels in their serum.},
  author={P. Kongtawelert and P. Brooks and P. Ghosh},
  journal={The Journal of rheumatology},
  year={1989},
  volume={16 11},
  pages={
          1454-9
        }
}
  • P. Kongtawelert, P. Brooks, P. Ghosh
  • Published 1989
  • Medicine
  • The Journal of rheumatology
  • The intraarticular injection of a sterile solution of 25 mg hydrocortisone succinate into rabbit knee joints once a week for 8 weeks reduced the levels of proteoglycans and hyaluronic acid (HA) in articular cartilage. In contrast, the keratan sulfate (KS) peptide levels present in sera of these animals were elevated relative to a saline treated control group. By injecting 25 mg hydrocortisone succinate combined with pentosan polysulfate (Cartrophen) (5 mg) into rabbit joints over the 8 week… CONTINUE READING
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