The effect of anesthetics on the membrane potential of spinal alpha-motoneurons was studied in awake-intact cats that were sequentially anesthetized with either halothane or pentobarbital. Pentobarbital (35 mg/kg) and halothane (5%) both induced a 5 mV hyperpolarization and a reduction in spontaneous synaptic activity of motoneurons. We suggest that a reduction in the urinary EPSP frequencies contributes to the hyperpolarization and the membrane potential criterion of acceptable impalements of motoneurons in awake-intact preparations should be 5 mV more depolarized than that in anesthetized preparations.

Cite this paper

@article{Whitney1986PentobarbitalAH, title={Pentobarbital and halothane hyperpolarize cat alpha-motoneurons.}, author={J. F. Whitney and Lee Angelich Raymond Arjo Patricia Auyong Michele Bailey Gary Ball Timothy Barkas Thomas Boland Linda Bradford Victoria Bray Hugh Bream Jim Brown Cheryl Brunk John Buck III Meggan Bunce Bruce Butler Samuel Caldwell Diane Campagna Geoffrey Capell Mark Capritto William Carll Leigh Cole Glenn}, journal={Brain research}, year={1986}, volume={381 1}, pages={199-203} }