Pentamidine Congeners 1: Synthesis of Cis- and Trans-Butamidine Analogues As Anti-Pneumocystis carinii Pneumonia Agents.

@article{Donkor1993PentamidineC1,
  title={Pentamidine Congeners 1: Synthesis of Cis- and Trans-Butamidine Analogues As Anti-Pneumocystis carinii Pneumonia Agents.},
  author={I. Donkor and S. Jones and R. Tidwell},
  journal={Bioorganic & medicinal chemistry letters},
  year={1993},
  volume={3 6},
  pages={
          1137-1140
        }
}
  • I. Donkor, S. Jones, R. Tidwell
  • Published 1993
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • Butamidine analogues possessing unsaturation in the ether bridge between the bisamidinophenyl or bisimidazolinophenyl functionalities have been synthesized as semirigid congeners of pentamidine. These compounds demonstrated good anti-P. carinii pueumonia activity in a rat model of the disease. 
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