Pentagalloylglucose downregulates cofilin1 and inhibits HSV-1 infection.


To investigate the anti-herpesvirus mechanism of pentagalloylglucose (PGG), we compared the proteomic changes between herpes simplex virus type 1 (HSV-1) infected MRC-5 cells with or without PGG-treatment, and between non-infected MRC-5 cells with or without PGG-treatment by 2-DE and MS-based analysis. Differentially expressed cellular proteins were mainly involved with actin cytoskeleton regulation. Significantly, PGG can down-regulate cofilin1, a key regulator of actin cytoskeleton dynamics. PGG can inhibit HSV-1-induced rearrangements of actin cytoskeleton which is important for infectivity. Furthermore, cofilin1 knockdown by siRNA also inhibited the HSV-1-induced actin-skeleton rearrangements. Both PGG-treatment and cofilin1 knockdown can reduce HSV-1 DNA, mRNA, protein synthesis and virus yields. Altogether, the results suggested that down-regulating cofilin1 plays a role in PGG inhibiting HSV-1 infection. PGG may be a promising anti-herpesvirus agent for drug development.

DOI: 10.1016/j.antiviral.2010.11.012
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@article{Pei2011PentagalloylglucoseDC, title={Pentagalloylglucose downregulates cofilin1 and inhibits HSV-1 infection.}, author={Ying Pei and Yang-fei Xiang and Jia-nan Chen and Chunhua Lu and Jing Hao and Qian Du and Chi-choi Lai and Chang Qu and Shen Li and Huai-qiang Ju and Zhe Ren and Qiu-ying Liu and Sheng Ming Xiong and Chui-wen Qian and Fan-Li Zeng and Pei-zhuo Zhang and Chong-ren Yang and Ying-Jun Zhang and Jun Xu and Kaio Kitazato and Yi-fei Wang}, journal={Antiviral research}, year={2011}, volume={89 1}, pages={98-108} }