Pentaerythritol tetranitrate and metabolites in rat plasma.

  title={Pentaerythritol tetranitrate and metabolites in rat plasma.},
  author={M C Crew and M D Melgar and F J di Carlo},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={192 1},
Intact pentaerythritol (PE) tetranitrate and all seven of its metabolites were present in blood withdrawn from the hearts of rats dosed by gavage with 14-C-PE tetranitrate (10 mg/kg). The plasma half-life (T 1/2) of PE tetranitrate was 2 hours which is far longer than the rat T 1/2 values of all other organic nitrates in clinical use. PE trinitrate, the… CONTINUE READING