Pentachlorobutadienyl-L-cysteine uncouples oxidative phosphorylation by dissipating the proton gradient.

@article{Schnellmann1989PentachlorobutadienylLcysteine,
  title={Pentachlorobutadienyl-L-cysteine uncouples oxidative phosphorylation by dissipating the proton gradient.},
  author={Rick G Schnellmann and T J Cross and Edward A. Lock},
  journal={Toxicology and applied pharmacology},
  year={1989},
  volume={100 3},
  pages={498-505}
}
A very early event in the toxicity of pentachlorobutadienyl-L-cysteine (PCBC) to rabbit renal proximal tubules is uncoupling of oxidative phosphorylation (R.G. Schnellmann, E. A. Lock, and L. J. Mandel (1986), Toxicologist 6, 176; (1987), Toxicol. Appl. Pharmacol. 90, 521). The mechanism of PCBC uncoupling of mitochondrial oxidative phosphorylation has been investigated using isolated rabbit renal cortical mitochondria (RCM). PCBC increased state 4 respiration of RCM respiring on pyruvate… CONTINUE READING