Pentacecilides, new inhibitors of lipid droplet formation in mouse macrophages, produced by Penicillium cecidicola FKI-3765-1: I. Taxonomy, fermentation, isolation and biological properties

@article{Yamazaki2009PentacecilidesNI,
  title={Pentacecilides, new inhibitors of lipid droplet formation in mouse macrophages, produced by Penicillium cecidicola FKI-3765-1: I. Taxonomy, fermentation, isolation and biological properties},
  author={Hiroyuki Yamazaki and Kakeru Kobayashi and Daisuke Matsuda and Ken'ichi Nonaka and Rokuro Masuma and Satoshi Ōmura and Hiroshi Tomoda},
  journal={The Journal of Antibiotics},
  year={2009},
  volume={62},
  pages={195-200}
}
New compounds designated pentacecilides A to C were isolated from the fermentation broth of Penicillium cecidicola FKI-3765-1 by solvent extraction, silica gel column chromatography and preparative HPLC. Pentacecilides A and B dose-dependently inhibited lipid droplet formation in mouse macrophages. Furthermore, pentacecilides A and B were found to inhibit the synthesis of cholesteryl ester in mouse macrophages with respective IC50 values of 3.65 and 4.76 μM without any cytotoxic effect, but… 
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Pentacecilides, new inhibitors of lipid droplet formation in mouse macrophages produced by Penicillium cecidicola FKI-3765-1: II. Structure elucidation

The structures of pentacecilides, new inhibitors of lipid droplet formation in mouse macrophages produced by Penicillium cecidicola FKI-3765-1, were elucidated by spectroscopic studies, including…

Absolute stereochemistry of pentacecilides, new inhibitors of lipid droplet formation in mouse macrophages, produced by Penicillium cecidicola FKI-3765-1

The structure of a new pentacellide congener, pentacecilide D, produced by Penicillium cecidicola FKI-3765-1 was elucidated by various NMR experiments and the inhibitory activity of all pentACEcilides against lipid droplet formation and acyl-CoA:cholesterol acyltransferase isozymes was compared.

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High-Throughput Screening of Australian Marine Organism Extracts for Bioactive Molecules Affecting the Cellular Storage of Neutral Lipids

It is found that heterofibrin A1 significantly reduces the intracellular accumulation of fatty acids and results in the formation of distinct fatty acid metabolites in both cultured cells and in embryos of the zebrafish Danio rerio.

A Mixture of Atropisomers Enhances Neutral Lipid Degradation in Mammalian Cells with Autophagy Induction

Results reveal that DPAmix enhances neutral lipid degradation together with induction of autophagy and causes dose-dependent induction of microtubule-associated protein light chain 3-II (LC3-II) and degradation of p62.

Characterization of a bioactive meroterpenoid isolated from the marine-derived fungus Talaromyces sp.

The new compound taladrimanin A (1) inhibits the growth of gastric cancer cells MGC803 and MKN28 as well as the pathogenic bacteria Staphylococcus aureus 6538P.

Exploration of marine natural resources in Indonesia and development of efficient strategies for the production of microbial halogenated metabolites

  • H. Yamazaki
  • Biology, Chemistry
    Journal of natural medicines
  • 2021
This review presents an overview of the recent work accomplishments based on the MONOTORI study, and the unique biological properties of marine organohalides are discussed herein and attempts to efficiently produce fungal halogenated metabolites are documented.

Chapter 6 – Drimane-Related Merosesquiterpenoids, a Promising Library of Metabolites for Drug Development

Fungal Partially Reducing Polyketides and Related Natural Products From Aspergillus, Penicillium, and Talaromyces

Chrodrimanins I and J from the Antarctic Moss-Derived Fungus Penicillium funiculosum GWT2-24.

Two new meroterpenoids, named chrodrimanins I and J (1 and 2), were isolated from the culture of the Antarctic moss-derived fungus Penicillium funiculosum GWT2-24 and possess a unique cyclohexanone (E ring) instead of a δ-lactone ring.

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Pentacecilides, new inhibitors of lipid droplet formation in mouse macrophages produced by Penicillium cecidicola FKI-3765-1: II. Structure elucidation

The structures of pentacecilides, new inhibitors of lipid droplet formation in mouse macrophages produced by Penicillium cecidicola FKI-3765-1, were elucidated by spectroscopic studies, including…

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