Penile erection induced in vivo by a purified toxin from the Brazilian spider Phoneutria nigriventer

@article{Andrade2008PenileEI,
  title={Penile erection induced in vivo by a purified toxin from the Brazilian spider Phoneutria nigriventer},
  author={Enrico Andrade and Fabiola Villanova and P. Borra and K. Leite and L. Troncone and I. Cortez and Leonardo E. Messina and M{\'a}rio Paranhos and Joaquim Claro and M. Srougi},
  journal={BJU International},
  year={2008},
  volume={102}
}
  • Enrico Andrade, Fabiola Villanova, +7 authors M. Srougi
  • Published 2008
  • Medicine
  • BJU International
    • To verify the effect on erectile tissue of mice of two neuropeptides extracted from the poison of a spider, Phoneutria nigriventer, (Tx2‐5 and ‐6, termed ‘eretina’) after direct injection into the corpus cavernosum, to assess the minimum dosage necessary for effect, the time for initiation of action, the local duration of the erection, histological effects and the presence of local and systemic side‐effects. 
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    21 Citations
    Highly Influencial Citations
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    Background Citations
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    Methods Citations
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    21 Citations
    Citation Type

    Citation Type

    Erection induced by Tx2-6 toxin of Phoneutria nigriventer spider: expression profile of genes in the nitric oxide pathway of penile tissue of mice.
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    New insights on arthropod toxins that potentiate erectile function.
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    Erectile function is improved in aged rats by PnTx2-6, a toxin from Phoneutria nigriventer spider venom.
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    The effect of PnTx2-6 protein from Phoneutria nigriventer spider toxin on improvement of erectile dysfunction in a rat model of cavernous nerve injury.
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    From the stretcher to the pharmacy's shelf: drug leads from medically important brazilian venomous arachnid species.
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    PnPP-19, a Synthetic and Nontoxic Peptide Designed from a Phoneutria nigriventer Toxin, Potentiates Erectile Function via NO/cGMP.
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    Functional expression of a recombinant toxin - rPnTx2-6 - active in erectile function in rat.
    • 14
    Increased cavernosal relaxation by Phoneutria nigriventer toxin, PnTx2-6, via activation at NO/cGMP signaling
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    Arachnids of medical importance in Brazil: main active compounds present in scorpion and spider venoms and tick saliva
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    Nitric oxide-induced vasorelaxation in response to PnTx2-6 toxin from Phoneutria nigriventer spider in rat cavernosal tissue.
    • 18

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