Penile erection induced in vivo by a purified toxin from the Brazilian spider Phoneutria nigriventer

  title={Penile erection induced in vivo by a purified toxin from the Brazilian spider Phoneutria nigriventer},
  author={Enrico Andrade and Fabiola Villanova and P. Borra and K. Leite and L. Troncone and I. Cortez and Leonardo E. Messina and M{\'a}rio Paranhos and Joaquim Claro and M. Srougi},
  journal={BJU International},
  • Enrico Andrade, Fabiola Villanova, +7 authors M. Srougi
  • Published 2008
  • Medicine
  • BJU International
  • To verify the effect on erectile tissue of mice of two neuropeptides extracted from the poison of a spider, Phoneutria nigriventer, (Tx2‐5 and ‐6, termed ‘eretina’) after direct injection into the corpus cavernosum, to assess the minimum dosage necessary for effect, the time for initiation of action, the local duration of the erection, histological effects and the presence of local and systemic side‐effects. 
    21 Citations
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    Erectile function is improved in aged rats by PnTx2-6, a toxin from Phoneutria nigriventer spider venom.
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    Functional expression of a recombinant toxin - rPnTx2-6 - active in erectile function in rat.
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    Isolation of neurotoxic peptides from the venom of the 'armed' spider Phoneutria nigriventer.
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    Isolation and partial characterization of a polypeptide from Phoneutria nigriventer spider venom that relaxes rabbit corpus cavernosum in vitro.
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    Blockade of neuronal nitric oxide synthase abolishes the toxic effects of Tx2-5, a lethal Phoneutria nigriventer spider toxin.
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