Penile erection induced in vivo by a purified toxin from the Brazilian spider Phoneutria nigriventer
@article{Andrade2008PenileEI, title={Penile erection induced in vivo by a purified toxin from the Brazilian spider Phoneutria nigriventer}, author={Enrico F m Andrade and Fabiola Villanova and Priscila Borra and Katia R M Leite and Lanfranco R Troncone and Italo Valle Cortez and Leonardo E. Messina and M{\'a}rio Paranhos and Joaquim F. A. Claro and Miguel Srougi}, journal={BJU International}, year={2008}, volume={102} }
To verify the effect on erectile tissue of mice of two neuropeptides extracted from the poison of a spider, Phoneutria nigriventer, (Tx2‐5 and ‐6, termed ‘eretina’) after direct injection into the corpus cavernosum, to assess the minimum dosage necessary for effect, the time for initiation of action, the local duration of the erection, histological effects and the presence of local and systemic side‐effects.
21 Citations
Erection induced by Tx2-6 toxin of Phoneutria nigriventer spider: expression profile of genes in the nitric oxide pathway of penile tissue of mice.
- BiologyToxicon : official journal of the International Society on Toxinology
- 2009
New insights on arthropod toxins that potentiate erectile function.
- BiologyToxicon : official journal of the International Society on Toxinology
- 2013
Erectile function is improved in aged rats by PnTx2-6, a toxin from Phoneutria nigriventer spider venom.
- Biology, MedicineThe journal of sexual medicine
- 2012
PnTx2-6 improves penile relaxation in aged rats, via increased NOS activity and NO release, resulting in enhanced cGMP levels.
The effect of PnTx2-6 protein from Phoneutria nigriventer spider toxin on improvement of erectile dysfunction in a rat model of cavernous nerve injury.
- BiologyUrology
- 2014
From the stretcher to the pharmacy's shelf: drug leads from medically important brazilian venomous arachnid species.
- BiologyInflammation & allergy drug targets
- 2011
The present work reviews the state of the art pertaining to venom molecules from Brazilian medically important arachnid species bearing potential biotechnological applications and isolates toxins isolated from the scorpion Tityus serrulatus and the spiders Phoneutria nigriventer and Lycosa erythrognatha.
PnPP-19, a Synthetic and Nontoxic Peptide Designed from a Phoneutria nigriventer Toxin, Potentiates Erectile Function via NO/cGMP.
- Biology, MedicineThe Journal of urology
- 2015
Functional expression of a recombinant toxin - rPnTx2-6 - active in erectile function in rat.
- BiologyToxicon : official journal of the International Society on Toxinology
- 2010
Increased cavernosal relaxation by Phoneutria nigriventer toxin, PnTx2-6, via activation at NO/cGMP signaling
- BiologyInternational Journal of Impotence Research
- 2012
It is concluded that PnTx2-6 facilitates penile relaxation in diabetic mice through a mechanism dependent on nNOS, probably via increasing nitric oxide/cGMP production.
Arachnids of medical importance in Brazil: main active compounds present in scorpion and spider venoms and tick saliva
- BiologyJournal of Venomous Animals and Toxins including Tropical Diseases
- 2015
The main components present in spider and scorpion venom as well as in tick saliva are described, since they have similar components, and potential biotechnological applications of some components with important biological activities are shown.
Nitric oxide-induced vasorelaxation in response to PnTx2-6 toxin from Phoneutria nigriventer spider in rat cavernosal tissue.
- BiologyThe journal of sexual medicine
- 2010
It is shown that PnTx2-6 slows Na(+) channels inactivation in nitrergic neurons, allowing Ca(2+) influx to facilitate NO/cGMP signalling, which promotes increased NO production.
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