Penicillin concentrations in serum, milk, and urine following intramuscular and subcutaneous administration of increasing doses of procaine penicillin G in lactating dairy cows.

@article{Dubreuil2001PenicillinCI,
  title={Penicillin concentrations in serum, milk, and urine following intramuscular and subcutaneous administration of increasing doses of procaine penicillin G in lactating dairy cows.},
  author={Pascal Dubreuil and Jocelyne Daigneault and Yvon Couture and P S Guay and Donald Landry},
  journal={Canadian journal of veterinary research = Revue canadienne de recherche veterinaire},
  year={2001},
  volume={65 3},
  pages={173-80}
}
Eight healthy, non-pregnant, crossbred Holstein dairy cows (557-682 kg) within their first 3 months of lactation (13-21.5 kg of milk/day) were used. Cows were kept in tie stalls for the whole experiment. The 8 cows were randomly assigned to 2 (IM and SC) 4 x 4 balanced Latin square design experiments. Doses of procaine penicillin G (PPG) (300000 IU/mL) in each square were 7000, 14000, 21000 and 28000 IU/kg and were injected IM or SC once daily for 5 consecutive days. Volumes of PPG per site of… CONTINUE READING