Penicillin binding proteins of Vibrio cholerae.

  title={Penicillin binding proteins of Vibrio cholerae.},
  author={Tapas K Sengupta and A N Chatterjee and Jagattaran Das},
  journal={Biochemical and biophysical research communications},
  volume={171 3},
Eleven penicillin binding proteins (PBPs) of Vibrio cholerae have been identified using [125I] labelled p-hydroxybenzyl penicillin (PenX). These proteins are localised in the inner membrane and have molecular weights ranging from 97,000 to 22,000. Neutral hydroxylamine released the labelled PenX from the PBPs and pretreatment with cold benzyl penicillin inhibited labelling completely. The PBP 4 is the most sensitive target for cephaloridine and aztreonam. Cephaloridine also binds to three other… CONTINUE READING