Penicillin-binding proteins in Clostridium perfringens.

  title={Penicillin-binding proteins in Clostridium perfringens.},
  author={Timothy F. Murphy and Michael Barza and James T. Park},
  journal={Antimicrobial agents and chemotherapy},
  volume={20 6},
The penicillin-binding proteins (PBPs) of Clostridium perfringens were studied. Six PBPs ranging in molecular weight from approximately 42,000 to 100,000 were detected in the cytoplasmic membrane. The relative affinities of the PBPs for 16 beta-lactam antibiotics were determined. Most of the drug saturated PBP 3 and 4 at concentrations equal to their minimal inhibitory concentrations, suggesting that these PBPs are the killing targets for beta-lactams. Mecillinam showed unique properties; it… CONTINUE READING


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