Penicillin binding proteins: key players in bacterial cell cycle and drug resistance processes.

@article{Macheboeuf2006PenicillinBP,
  title={Penicillin binding proteins: key players in bacterial cell cycle and drug resistance processes.},
  author={Pauline Macheboeuf and Carlos Contreras-Martel and Viviana Job and Otto Dideberg and Andr{\'e}a Dessen},
  journal={FEMS microbiology reviews},
  year={2006},
  volume={30 5},
  pages={673-91}
}
Bacterial cell division and daughter cell formation are complex mechanisms whose details are orchestrated by at least a dozen different proteins. Penicillin-binding proteins (PBPs), membrane-associated macromolecules which play key roles in the cell wall synthesis process, have been exploited for over 70 years as the targets of the highly successful beta-lactam antibiotics. The increasing incidence of beta-lactam resistant microorganisms, coupled to progress made in genomics, genetics and… CONTINUE READING
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