Penicillin-Binding Proteins (PBPs) and Bacterial Cell Wall Elongation Complexes.

@article{Miyachiro2019PenicillinBindingP,
  title={Penicillin-Binding Proteins (PBPs) and Bacterial Cell Wall Elongation Complexes.},
  author={Mayara Mayele Miyachiro and Carlos Contreras-Martel and Andr{\'e}a Dessen},
  journal={Sub-cellular biochemistry},
  year={2019},
  volume={93},
  pages={
          273-289
        }
}
The bacterial cell wall is the validated target of mainstream antimicrobials such as penicillin and vancomycin. Penicillin and other β-lactams act by targeting Penicillin-Binding Proteins (PBPs), enzymes that play key roles in the biosynthesis of the main component of the cell wall, the peptidoglycan. Despite the spread of resistance towards these drugs, the bacterial cell wall continues to be a major Achilles' heel for microbial survival, and the exploration of the cell wall formation… 
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