Penicillin Binding Protein 1 Is Important in the Compensatory Response of Staphylococcus aureus to Daptomycin-Induced Membrane Damage and Is a Potential Target for β-Lactam-Daptomycin Synergy.

@article{Berti2016PenicillinBP,
  title={Penicillin Binding Protein 1 Is Important in the Compensatory Response of Staphylococcus aureus to Daptomycin-Induced Membrane Damage and Is a Potential Target for β-Lactam-Daptomycin Synergy.},
  author={Andrew D. Berti and Erin M. Theisen and John-Demian Sauer and Poochit Nonejuie and Joshua Olson and Joseph Pogliano and George Sakoulas and Victor Nizet and Richard A. Proctor and Warren E. Rose},
  journal={Antimicrobial agents and chemotherapy},
  year={2016},
  volume={60 1},
  pages={451-8}
}
The activity of daptomycin (DAP) against methicillin-resistant Staphylococcus aureus (MRSA) is enhanced in the presence of β-lactam antibiotics. This effect is more pronounced with β-lactam antibiotics that exhibit avid binding to penicillin binding protein 1 (PBP1). Here, we present evidence that PBP1 has a significant role in responding to DAP-induced… CONTINUE READING