Penicillin: the medicine with the greatest impact on therapeutic outcomes

@article{Kardos2011PenicillinTM,
  title={Penicillin: the medicine with the greatest impact on therapeutic outcomes},
  author={Nelson Kardos and Arnold L. Demain},
  journal={Applied Microbiology and Biotechnology},
  year={2011},
  volume={92},
  pages={677-687}
}
The principal point of this paper is that the discovery of penicillin and the development of the supporting technologies in microbiology and chemical engineering leading to its commercial scale production represent it as the medicine with the greatest impact on therapeutic outcomes. Our nomination of penicillin for the top therapeutic molecule rests on two lines of evidence concerning the impact of this event: (1) the magnitude of the therapeutic outcomes resulting from the clinical application… 
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