Penicillamine therapy for pediatric cystinuria: experience from a cohort of American children.

@article{DeBerardinis2008PenicillamineTF,
  title={Penicillamine therapy for pediatric cystinuria: experience from a cohort of American children.},
  author={Ralph J DeBerardinis and Curtis R Coughlin and Paige B Kaplan},
  journal={The Journal of urology},
  year={2008},
  volume={180 6},
  pages={
          2620-3
        }
}
PURPOSE Cystinuria, an inherited defect of dibasic amino acid transport, causes accumulation of urinary cystine and cystine urolithiasis. In adults penicillamine reduces stone formation but has a high incidence of dose limiting toxicity. We evaluated the effects of penicillamine in preventing stone formation and with respect to toxicity in our cystinuria cohort at a pediatric biochemical genetics clinic. MATERIALS AND METHODS We reviewed the charts of all 11 children with cystinuria treated… CONTINUE READING

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