Penetration of ofloxacin into human lung tissue following a single oral dose of 200 milligrams.

Abstract

The penetration of ofloxacin into lung tissue was studied in 10 patients subjected to pulmonary surgery. Samples of blood and lung tissue were obtained 3 to 8 h (mean, 5 h) after oral administration of 200 mg. The mean level in tissue was 2.17 +/- 0.5 micrograms/g, while the mean level in serum was 0.85 +/- 0.23 micrograms/ml. The mean lung tissue/serum concentration ratio was 2.55 +/- 0.30. The achievable levels of ofloxacin in lung tissue are above the MICs for most pulmonary pathogens.

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@article{Serour1991PenetrationOO, title={Penetration of ofloxacin into human lung tissue following a single oral dose of 200 milligrams.}, author={Francis Serour and Michael D. Dan and Alfred Gorea and Alon Yellin and Y. Lieberman and Stephen A. Berger}, journal={Antimicrobial agents and chemotherapy}, year={1991}, volume={35 2}, pages={380-1} }