Penetration of intravenous hydroxyethyl starch into the cerebrospinal fluid in patients with impaired blood-brain barrier function.

@article{Dieterich2003PenetrationOI,
  title={Penetration of intravenous hydroxyethyl starch into the cerebrospinal fluid in patients with impaired blood-brain barrier function.},
  author={H J Dieterich and J{\"o}rg Reutershan and Thomas W. Felbinger and Holger K. Eltzschig},
  journal={Anesthesia and analgesia},
  year={2003},
  volume={96 4},
  pages={1150-4, table of contents}
}
UNLABELLED Hypovolemic patients with impairment of the blood-brain barrier may receive IV hydroxyethyl starch (HES) to stabilize cardiovascular function and to increase cerebral perfusion pressure. It is not known whether HES can penetrate into the cerebrospinal fluid (CSF) under those conditions. We investigated plasma and CSF levels of HES after IV infusion in patients with suspected disturbance of the blood-brain barrier. Eight adult patients were studied who were being treated for head… CONTINUE READING