Penetration of interleukin-6 across the murine blood-brain barrier

@article{Banks1994PenetrationOI,
  title={Penetration of interleukin-6 across the murine blood-brain barrier},
  author={William A. Banks and Abba J. Kastin and Enrique G. Gutierrez},
  journal={Neuroscience Letters},
  year={1994},
  volume={179},
  pages={53-56}
}
Ovine Proinflammatory Cytokines Cross the Murine Blood-Brain Barrier by a Common Saturable Transport Mechanism
TLDR
Ovine IL-1β and IL-6 cross the mouse blood-brain barrier (BBB) by saturable transport and an inability of ovine cytokines to significantly inhibit the transport of murine cytokine indicates that mouse BBB has a lower affinity for ovine than murineinflammatory cytokines.
Clearance of 125I-labeled interleukin-6 from brain into blood following intracerebroventricular injection in rats.
TLDR
Direct secretion of IL-6 from brain to blood may be a mechanism by which the brain modifies peripheral metabolic, endocrine, and immune activity.
Permeation of growth hormone across the blood-brain barrier.
TLDR
It is found that both mice and rats have small but significant uptake of GH into the brain without a species difference, adding definitive value to the long-disputed question of whether and how GH crosses the BBB.
The proinflammatory cytokine network: interactions in the CNS and blood of rhesus monkeys.
  • T. Reyes, C. Coe
  • Biology, Medicine
    The American journal of physiology
  • 1998
TLDR
This research extends studies of the cytokine cascade to the central nervous system (CNS), highlighting the brain response to peripheral activation and measuring cytokines in blood and CSF from juvenile rhesus monkeys after intravenous administration of cytokines.
The proinflammatory cytokine network: interactions in the CNS and blood of rhesus monkeys.
  • T. Reyes, C. Coe
  • Biology, Medicine
    American journal of physiology. Regulatory, integrative and comparative physiology
  • 1998
TLDR
This research extends studies of the cytokine cascade to the central nervous system (CNS), highlighting the brain response to peripheral activation and measuring cytokines in blood and cerebrospinal fluid from juvenile rhesus monkeys after intravenous administration of cytokines.
Interleukin-1β Transfer across the Blood–Brain Barrier in the Ovine Fetus
  • G. Sadowska, Xiaodi Chen, B. Stonestreet
  • Biology, Medicine
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2015
TLDR
Altered BBB function after hypoxia–ischemia facilitates entry of systemic cytokines into the brain of the fetus and it is concluded that systemic IL-1β crosses the intact fetal BBB, and that ischemia–reperfusion increases transfer of this cytokine across the fetal BBBs.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 22 REFERENCES
Human interleukin (IL) 1 alpha, murine IL-1 alpha and murine IL-1 beta are transported from blood to brain in the mouse by a shared saturable mechanism.
TLDR
It is shown thatRadioiodinated murine IL-1 beta and especially murineIL-1 alpha are even more rapidly transported into the brain of the mouse than is radioiodinated human IL- 1 alpha after i.v. injection, showing that there are not three separate transport systems, but that they either share transport systems with overlapping affinities or share a single system.
Role of interleukin 6 in fever in rats.
TLDR
The results of this study are consistent with the hypothesis that IL-6 is a mediator of LPS-induced fever in the rat, and the core temperature rose significantly after intracerebroventricular injection of recombinant human IL- 6.
A central mechanism is involved in the secretion of ACTH in response to IL-6 in rats: comparison to and interaction with IL-1 beta.
TLDR
Evaluated the effect of IL-6 on ACTH secretion and its interaction with IL-1 beta to determine if the action ofIL-6 was at a site(s) within the brain, and found that IL- 6 elevated ACTH in a dose-dependent manner and that IL,1 beta was significantly more effective.
...
1
2
3
...