Penetration of erythromycin through respiratory mucosa. A study using secretory otitis media as a model.

@article{Sundberg1979PenetrationOE,
  title={Penetration of erythromycin through respiratory mucosa. A study using secretory otitis media as a model.},
  author={L B Sundberg and Tim O B Eden and S Ernstson and R Pahlitzsch},
  journal={Acta oto-laryngologica. Supplementum},
  year={1979},
  volume={365},
  pages={
          1-17
        }
}
This study is based upon the concept that the respiratory mucosa reacts in a uniform manner to an inflammatory stimulus. Secretory Otitis Media (SOM) may be used as a model to disclose some aspects of antibiotic penetration. Erythromycin was given for different periods of time to 108 cases of SOM where myringotomy was indicated. The middle ear effusion was aspirated and blood samples were obtained simultaneously. The concentration of erythromycin was determined by microbiological procedures… CONTINUE READING

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