Penetration of diazepam and the non-peptide CCK antagonist, L-364,718, into rat brain.

@article{Pullen1987PenetrationOD,
  title={Penetration of diazepam and the non-peptide CCK antagonist, L-364,718, into rat brain.},
  author={Robert L. Pullen and O J Hodgson},
  journal={The Journal of pharmacy and pharmacology},
  year={1987},
  volume={39 10},
  pages={
          863-4
        }
}
Interest in the actions of the peptide cholecystokinin (CCK) has led to the design and synthesis of several non-peptide CCK antagonists, the most recent being that produced by Merck Sharp & Dohme and designated L-364, 718. This can be viewed as modified D-tryptophan linked to diazepam (1-methyl-3-(2-indoloyl)amino-5-phenyl-3H-1,4-benzodiazepin-2-one) 1. 

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