Penetration of cisplatin into mouse brain by lipopolysaccharide.

  title={Penetration of cisplatin into mouse brain by lipopolysaccharide.},
  author={Toshiaki Minami and Jiro Okazaki and Atsufumi Kawabata and Ryotaro Kuroda and Yuko Okazaki},
  volume={130 2-3},
We investigated the penetration of cisplatin into the mouse cerebral cortex-rich region (CCR) induced by lipopolysaccharide (LPS). With the injection of cisplatin into mice 3 h after the LPS treatment, platinum was detected in the CCR during the 7 days after the injection, while platinum was not detected in the CCR of cisplatin-injected mice without LPS pretreatment and of mice simultaneous treated with cisplatin and LPS. The N(G)-nitro-L-arginine methyl ester dose-dependently lowered the… CONTINUE READING

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