Penetration of Ufenamate into Intact, Stripped, or Delipidized Skin Using Different Vehicles.

  title={Penetration of Ufenamate into Intact, Stripped, or Delipidized Skin Using Different Vehicles.},
  author={Hayato Iino and M. Fujii and Manami Fujino and N. Koizumi and Yoshiteru Watanabe},
  journal={Biological \& pharmaceutical bulletin},
  volume={38 10},
The purpose of this study was to clarify the effect of skin condition on skin penetration of the very high lipophilic drug, ufenamate (UF). UF was applied to stripped or delipidized skin using liquid paraffin (LP) or purified water containing polysorbate 80 at a dose of 2 µL/cm(2). We found that UF penetration into intact and stripped skin using a water vehicle was respectively 5 and 10 times higher than that using LP. UF is freely soluble in oil and insoluble in water; thus, activity in water… Expand
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