Penetration of Antimicrobial Agents into the Prostate

@article{Charalabopoulos2003PenetrationOA,
  title={Penetration of Antimicrobial Agents into the Prostate},
  author={K. Charalabopoulos and G. Karachalios and D. Baltogiannis and A. Charalabopoulos and X. Giannakopoulos and N. Sofikitis},
  journal={Chemotherapy},
  year={2003},
  volume={49},
  pages={269 - 279}
}
In the present review article, the penetration of antimicrobial agents into prostatic fluid and tissue was examined. Three major factors determining the diffusion and concentration of antimicrobial agents in prostatic fluid and tissue are the lipid solubility, dissociation constant (pKa) and protein binding. The normal pH of human prostatic fluid is 6.5–6.7, and it increases in chronic prostatitis, ranging from 7.0 to 8.3. A greater concentration of antimicrobial agents in the prostatic fluid… Expand
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