Penetration enhancing effect of menthol on the percutaneous flux of nicardipine hydrochloride through excised rat epidermis from hydroxypropyl cellulose gels.

@article{Krishnaiah2002PenetrationEE,
  title={Penetration enhancing effect of menthol on the percutaneous flux of nicardipine hydrochloride through excised rat epidermis from hydroxypropyl cellulose gels.},
  author={Yellela S. R. Krishnaiah and Vemulapalli Satyanarayana and Rajapandian Sivaganesa Karthikeyan},
  journal={Pharmaceutical development and technology},
  year={2002},
  volume={7 3},
  pages={
          305-15
        }
}
The aim of the present investigation is to study the penetration enhancing effect of menthol on the percutaneous flux of nicardipine hydrochloride through the excised rat epidermis from 2% w/w hydroxypropyl cellulose (HPC) gel system. The HPC gel formulations containing nicardipine hydrochloride and selected concentrations of menthol (0-12% w/w) were prepared, and evaluated for in vitro permeation of the drug through excised rat abdominal epidermis. The percutaneous flux of nicardipine… CONTINUE READING

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