Penetrance of LRRK2 G2385R and R1628P is modified by common PD-associated genetic variants.

@article{Wang2012PenetranceOL,
  title={Penetrance of LRRK2 G2385R and R1628P is modified by common PD-associated genetic variants.},
  author={Chaodong Wang and Yanning Cai and Zheng Zheng and Bei-sha Tang and Yanming Xu and Tao Wang and Jinghong Ma and Shengdi Chen and James William Langston and Caroline M. Tanner and Piu Chan},
  journal={Parkinsonism & related disorders},
  year={2012},
  volume={18 8},
  pages={958-63}
}
Variants in the LRRK2 gene are well-characterized genetic predisposing factors for PD worldwide, and LRRK2-associated PD is often indistinguishable from idiopathic PD (IPD). However, considerable heterogeneity of LRRK2-PD suggests the existence of additional genetic and/or environmental modifiers for LRRK2 carriers, which have yet to be confirmed by large-scale human studies. In a Chinese cohort consisting of 2013 sporadic PD patients and 1971 controls, we investigated the modification of the… CONTINUE READING

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